Yifulou Building, College of Food Engineering & Biotechnology, Tianjin University of Science and Technology, TEDA, Tianjin, 300457, China
Dr Xu Wang is an associate professor of Food Engineering & Biotechnology, TianjinUniversity of Science & Technology. In June 2008, he obtained his Master Degree at the School of Pharmaceutical Science & Technology, TianjinUniversity. From Jul 2008 to Aug 2009, he worked as a scientist in the Department of Analytical R&D, WuXi AppTec in Shanghai. In Oct 2013, he started as a postdoctoral fellow in analytical department at Innovation R&D Center, Master Kong Holding Corp. In the beginning of 2016, he was promoted as a senior scientist to lead the analytical team and manage the R&D project. In Sept 2016, Dr Wang joined Tianjin University of Science & Technology. To bridge the gap between academia and industry, he has been driving impactful innovation with industry and dedicated himself to train young scientist in analytical sciences.
The challenge of current food safety issue is unknown hazards. To meet the increasing need of food industry, comprehensive and high throughput analytical platforms have been developed to screen potential risks in food and environment using high resolution Time of Flight Mass spectrometry. Analytical solutions including chromatography and capillary electrophoresis will be developed with regards to high sensitivity and selectivity.
Metabolomics has been becoming a comprehensive and sensitive tool in health assessment and the discovery of biomarkers in the early stage of health related diseases. The research will be focused on the development of target metabolomics and its application in food nutrition and life science. By working closely with our partners, we are devoted to looking for possible mechanism and intervention for human related chronic diseases.
There is also an increasing need to looking for possible cure from nutraceuticals or natural products towards human related chronic diseases. The main reason for failure of drug discovery is poor biopharmaceutical properties. Excellent in vitro efficacy can not always translate into in vivo activity unless it has good bioavailability. Simultaneous screening of binding property and pharmacokinetic properties was proposed in the early stage of drug discovery. The binding property of potential lead towards to a certain protein target like MMP will be studied including its IC50 and Ki. The in vivo bioavailability or ADME profile of the lead candidate will be investigated using LC-MS/MS based pharmacokinetics.
1.Wang X., Li K., Yao L., Wang C., Van Schepdael A.Recent advances in vitamins analysis by capillary electrophoresis, Journal of Pharmaceutical and Biomedical Analysis, 2018 ,147, 278–287
2.Wang X., Chen H., Li, K. Cao X., Fan Y., Chang C., Luo P., Deldicque L., Adams E., Van Schepdael. A. Study of the effect of short-term dietary nitrate supplementation on plasma matrix metalloproteinase-9 in healthy men. Chinese Journal of Pharmaceutical Analysis, 2016, 36, 98-103 3. Li K*,Wang X*, Pidatala VR, Chang CP, Cao X.Novel quantitative metabolomic approach for the study of stress responses of plant root metabolism.J Proteome Res. 2014, 13, 5879-5887. (*Co-first) 4.Wang X., Li K., Adams E., Van Schepdael A. Recent advances in CE-mediated microanalysis for enzyme study. Electrophoresis, 2014, 25, 119-127 5.Wang X., Li K., Adams E., Van Schepdael A. CE/MS in metabolomics: the potential for driving drug discovery. Current Drug Metabolism, 2013, 14, 807-813. 6.Wang X., Dou Z., Yuan Y., Man S., Wolfs K., Adams E., Van Schepdael A. On-line screening of Matrix Metalloproteinase Inhibitors by capillary electrophoresis coupled to ESI mass spectrometry. J. Chromatogr. B, 2013, 930, 48-53.
7.Wang X., Masschelein E., Hespel P., Adams E., Van Schepdael A., Simultaneous determination of nitrite and nitrate in human plasma by on capillary pre-concentration with field amplified sample stacking. Electrophoresis, 2012, 33, 402-405. 8.Wang X., Adams E., Van Schepdael A., A sensitive and fast method for the determination of nitrite in human plasma by capillary electrophoresis with fluorescence detection. Talanta, 2012, 97, 142-144.
9.Wang X., Li K., Adams E., Van Schepdael A. Matrix metalloproteinase inhibitors: A Review on Bioanalytical methods, Pharmacokinetics and Metabolism. Current Drug Metabolism, 2011, 12, 395-410. 10. Hai, X.*,Wang, X.*, El-Attug, M., Adams, E., Hoogmartens, J., Van Schepdael, A. In-Capillary Screening of Matrix Metalloproteinase Inhibitors by Electrophoretically Mediated Microanalysis with Fluorescence Detection. Anal. Chem. 2011, 83, 425-430. (*Co-first) 11.Wang X., Gao W., Zhang L., Xiao P. Study on the morphology, crystalline structure and thermal properties of yam starch acetates with different degrees of substitution. Science China Chemistry, 2008, 51, 859-865. 12. Chen H.,Wang X.,Chopra. S., Adams E., Van Schepdael A. Development and validation of an indirect pulsed electrochemical detection method for monitoring the inhibition of Abl1 tyrosine kinase. Journal of Pharmaceutical and Biomedical Analysis, 2013, 90, 52-57. 13. Gebreyohannes, Y.,Wang X., Weldu G., Adams E., Van Schepdael A. Development and validation of a HPLC method for the analysis of 3PO in biological samples . Chinese Journal of Pharmaceutical Analysis, 2013, 33, 1873-1876 14.Masschelein E,Van Thienen R,Wang X,Van Schepdael A,Thomis M,Hespel P. Dietary nitrate improves muscle but not cerebral oxygenation status during exercise in hypoxia.J Appl Physiol.2012, 113(5):736-45. Honors & Awards
2012 Junior Mobility Scholarship from University of Leuven, Belgium
2012 Travel Grant from Belgian Society of Pharmaceutical Sciences
2012 Young Scientist Award (28th International Microscale Bioseparation and Analyses, China)
2010 Jointed scholarship for excellent scholar from China and Belgium
Safety control in food processing for undergraduate students
Introduction to food safety for undergraduate students
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